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4 reasons why your HS is so itchy 1. Inflammation releases chemicals like histamine & cytokines which can trigger itch signals in the skin. 2. In HS, inflammation doesn’t always “shut off” when it’s supposed to. That ongoing inflammation can keep the skin & nerves irritated causing that persistent HS itch. 3. Healing skin can cause itchiness. New cells are forming, nerves are regenerating, & scar tissue is forming. 4. Dryness & dressing irritation. Bandages, drainage, and washing can dry the ski
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When I see patients with concerns for mast cell activation syndrome (MCAS), I often emphasize that this is a neuroimmune condition, meaning the immune system and nervous system are in constant communication. Mast cells sit very close to nerves and can be directly activated by stress signals like norepinephrine and CRH (corticotropin-releasing hormone). During a flare, the body often shifts toward a more sympathetic (“fight or flight”) state, which can further dysregulate mast cells and amplify s
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