In this video, AMBOSS presents care providers with an overview of sampling both the nasopharynx and oropharynx in suspected COVID-19 cases, an acute respiratory illness associated with infection by the SARS-CoV-2 virus. While a nasopharyngeal swab is the preferred testing method of the WHO and CDC, an oropharyngeal swab can also be conducted if necessary. When performing either type of swab, special care should be taken to reduce the risk of infection and ensure the reliability of swab results.