ALZFORUM | NETWORKING FOR A CURE
WEB3 days ago · On September 10, Francisco Lopera died of cancer in Medellin, Colombia. He was widely beloved. Lopera helped pioneer prevention trials of disease-modifying drugs after years spent assembling information on the world’s largest known kindred of autosomal-dominant Alzheimer’s disease caused by …
Donanemab | ALZFORUM
WEBFeb 14, 2019 · Overview. Name: Donanemab Synonyms: N3pG-Aβ Monoclonal Antibody, LY3002813, Kisunla Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Approved) Company: Eli Lilly & Co. Background. Donanemab, aka N3pG, is a humanized IgG1 monoclonal antibody developed from mouse mE8-IgG2a. This biologic drug …
Leqembi - ALZFORUM
WEBOverview. Name: Leqembi Synonyms: Lecanemab-irmb, BAN2401, mAb158 Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Approved) Company: BioArctic AB, Biogen, Eisai Co., Ltd. Background. BAN2401 is the humanized IgG1 version of the mouse monoclonal antibody mAb158, which selectively binds to large, soluble ...
5xFAD (B6SJL) - ALZFORUM
WEBJan 18, 2015 · 5xFAD mice express human APP and PSEN1 transgenes with a total of five AD-linked mutations: the Swedish (K670N/M671L), Florida (I716V), and London (V717I) mutations in APP, and the M146L and L286V mutations in PSEN1. Three lines were generated originally: Tg6799, Tg7031, and Tg7092. The Tg6799 line, which expresses the highest levels of mutant ...
Memantine—Good for a Year, But Little Disease Modification
WEBJan 16, 2018 · 12 Jan 2006. The drug memantine is a safe and effective therapy that helps patients suffering from moderate to severe Alzheimer disease for up to a year. However, evidence that the drug might slow the underlying pathology is weak. These are the two main conclusions of a 24-week, open-label extension of a 28-week, randomized clinical trial.
AL002 - ALZFORUM
WEBNov 6, 2023 · AL002a, a variant of AL002 that recognizes mouse TREM2, reportedly doubled the number of CD11b-positive microglia in cortex and hippocampus 72 hours after injection in APP/PS1 mice. Microglia expressed more pro-inflammatory and repair genes, and nearby amyloid deposits were nearly halved (Dec 2016 conference news).
Donepezil - ALZFORUM
WEBDonepezil's most common side effects are gastrointestinal, i.e., diarrhea, nausea, and vomiting; dizziness, sleeplessness/fatigue, and urinary incontinence also have been reported. These are known class effects of cholinergic therapies, and often occur primarily at the beginning of treatment. One post-hoc analysis reported an inverse ...
Trontinemab - ALZFORUM
WEBMay 9, 2024 · Overview. Name: Trontinemab Synonyms: RO7126209, RG6102 , Brain shuttle gantenerumab Therapy Type: Immunotherapy (passive) Target Type: Amyloid-Related Condition(s): Alzheimer's Disease U.S. FDA Status: Alzheimer's Disease (Phase 1/2) Company: Hoffmann-La Roche Background. RO7126209 is a new version of the anti-amyloid monoclonal antibody gantenerumab, engineered to more easily cross the blood ...
What Is Early Onset Familial Alzheimer Disease (eFAD)?
WEBEarly onset FAD is acutely tragic because the patient faces a relentless and progressive loss of brain function so prematurely, while he or she is still physically vigorous. As a result, eFAD is often accompanied by psychiatric complications such as depression and agitation.
APPPS1 - ALZFORUM
WEBJan 9, 2023 · Species: Mouse Genes: APP, PSEN1 Mutations: APP K670_M671delinsNL (Swedish), PSEN1 L166P Modification: APP: Transgenic; PSEN1: Transgenic Disease Relevance: Alzheimer's Disease Strain Name: B6.Cg-Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr Genetic Background: C57BL/6J Availability: Available through Mathias Jucker Summary. APPPS1 mice contain human transgenes for both APP …
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