Mayo, Florida is a town and the only municipality in Lafayette County, Florida, United States. It is the county seat of Lafayette County. [6] The population was 1,055 at the 2020 census.

Zillow has 51 homes for sale in Mayo FL. View listing photos, review sales history, and use our detailed real estate filters to find the perfect place.

Mayo, the county seat of Lafayette County, population 1,226, is small town America personified. If you are camping at nearby Lafayette Blue Springs State Park or the Suwannee River Rendezvous, then …

Get directions, maps, and traffic for Mayo, FL. Check flight prices and hotel availability for your visit.

Jan 14, 2026 · From Hurricane Helene’s devastating impact to community recovery and resilience, discover what’s been happening in Mayo and Lafayette County over the past two years.

Mayo Tourism: Tripadvisor has 376 reviews of Mayo Hotels, Attractions, and Restaurants making it your best Mayo resource.

At Mayo Clinic in Florida, world-class providers and dedicated volunteers help you feel welcomed and comforted as you experience safely delivered, innovative health care and clinical expertise that’s …

Nov 9, 2025 · Located in the heart of North Florida, Mayo offers a mix of outdoor adventures, local charm, and community spirit. Whether you enjoy fishing, hiking, or simply relaxing by the water, this …

Oct 23, 2024 · Mayo Florida is a small town in North Central Florida. It is famous for producing a Gator football folk hero.

Dec 20, 2024 · Mayo is a historic town with many things to offer visitors. Plenty of activities keep you busy, from exploring the state parks and wildlife management areas to horseback riding and diving.