Background ER2001 is a genetic circuit (plasmid) encoding both a neuron-targeting rabies virus glycoprotein (RVG) tag and an HTT siRNA. This circuit is able to reprogram liver cells to transcribe and ...

Professor N J Scolding, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK; n.j.scolding{at}bristol.ac.uk Methods: The frequency, nature, relationship to systemic features, ...

Department of Clinical Neurophysiology and Epilepsies, St Thomas’ Hospital, London SE1 7EH, UK Dr CP Panayiotopoulos, St Thomas’ Hospital, London SE1 7EH, UK. OBJECTIVES To describe the clinical and ...

OBJECTIVES To clarify whether different causative events (trauma, stroke, intracranial surgery), time of intervention, and treatment mode influence outcome, patients with fixed and dilated pupils ...

A 44-year-old, post-transplant female, presented with urosepsis and raised tacrolimus level. She developed focal motor seizures. She suffered long-standing type-1 diabetes, developing end-stage renal ...

Background Autopsy studies of former contact sports athletes, including soccer and rugby players, frequently report chronic traumatic encephalopathy, a neurodegenerative pathology associated with ...

Background and objective: A single session of repetitive transcranial magnetic stimulation (rTMS) over motor cortex had been reported to produce short term relief of some types of chronic pain. The ...

An increasing number of highly effective disease-modifying therapies for people with multiple sclerosis (MS) have recently gained marketing approval. While the beneficial effects of these drugs in ...

4 Department of Neurology, University of Southern California, Los Angeles, California, USA 5 Department of Neurology, Sanders-Brown Center on Aging, University of Kentucky, Lexington, Kentucky, USA 6 ...

MRC Centre for Neuromuscular Diseases, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK Correspondence to Professor Mary M Reilly, MRC Centre for ...

Background Staging of disease severity is useful for prognosis, decision-making and resource planning. However, no commonly used, validated staging system exists for amyotrophic lateral sclerosis (ALS ...

Correspondence to Jia Liu, Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology; jia.liu{at}siat.ac.cn and Dr Ka Sing Wong, Department of Medicine and Therapeutics, The Chinese ...