B lymphocytes develop from hematopoietic stem cells (HSCs) through intermediate lymphoid progenitors, which undergo lineage commitment and subsequently differentiate along the B cell pathway. The ...

Researchers led by a team at Baylor College of Medicine have identified a novel neurodevelopmental disorder associated with mutations or deletions affecting a gene called PAX5. Their findings are ...

Herein, we explored the effect of PAX5/ETV6 on the transcription in precursor B cells and whether the fusion gene specifically affects the PAX5 and ETV6 physiological pathways. We performed a ...

Researchers have discovered the molecular process by which the PAX5 protein, necessary for lymphocyte development, promotes the growth of common lymphomas, thereby unveiling a potential new target in ...

The research team’s scientific paper was published in the Journal of Clinical Investigation (JCI) and showed that 395 genes are differently expressed in the pancreatic islets in individuals with type ...

Oncology researchers have long believed the protein Pax5 is merely a “transcription factor,” meaning it helps cells transcribe vital genetic information. But scientists in Australia believe they’ve ...

Researchers have discovered the first inherited gene mutation linked exclusively to acute lymphoblastic leukemia (ALL) occurring in multiple relatives in individual families. The discovery of the PAX5 ...

A study by the Josep Carreras Leukaemia Research Institute reveals a mechanism that controls B-lymphocyte maturation, with SIRT7 playing a critical role. This insight could lead to new treatments for ...

The transcription factor Pax5 is essential for initiating B cell lineage commitment, but its role in maintaining commitment is unknown. Using conditional Pax5 inactivation in committed pro-B cells, we ...

Like cartographers completing a map, investigators have identified multiple new subtypes of the most common childhood cancer--research that will likely improve the diagnosis and treatment of high-risk ...