A collaborative study published in Immunity from the Batista Lab and Liu Lab at the Ragon Institute, together with the Schief ...

Germinal centers form in the body’s lymphatic tissues shortly after vaccination or infection. Once inside a germinal center, B cells undergo rapid mutations and, through a process of natural selection ...

If B cells are the munitions factories of the immune system, manufacturing antibodies to neutralize harmful pathogens, then the tiny biological structures known as germinal centers are its ...

The germinal centers that form in the body's lymph nodes work as a fitness boot camp in which B cells evolve to produce antibodies of increasingly higher affinity to an invading pathogen. This new ...

Researchers at the Ragon Institute and Scripps Research Institute have discovered that antibodies produced during immune responses act as a "brake" on B cell selection, preventing over-optimization ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted ...

The germinal center of the immune system plays a complicated dual role in the body: vitally selecting B cells secreting high-affinity antibodies to serve the immune system in the fight against foreign ...

A new study provides mechanistic insights into how live attenuated simian immunodeficiency virus (SIV) vaccines (LAVs) can protect monkeys from infection with pathogenic SIV. The authors show that ...

Four new studies led by Harvard Medical School researchers at Boston Children's Hospital reveal details about how B cells in the immune system churn out antibodies that become increasingly potent and ...