Week 2 NFL game highlights
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Wide receiver Ricky Pearsall and the San Francisco 49ers take on the New Orleans Saints in this Week 2 contest.
Seattle Seahawks kicker Jason Myers makes a 48-yard field goal before halftime of Sunday's divisional game against the San Francisco 49ers. Seattle Seahawks linebacker Ernest Jones IV ends the San Francisco 49ers' first drive of the second half with a leaping interception of quarterback Brock Purdy during Week 1 at Lumen Field.
See all the ways to watch, live stream, and listen to the New Orleans Saints vs San Francisco 49ers game on Sept. 14 in Week 2 of the 2025 NFL season
The San Francisco 49ers take on the New Orleans Saints at 10:05 a.m. PT on Sunday, Sept. 14 at the Caesars Superdome in New Orleans. The Niners are not expected to have quarterback Brock Purdy or tight end George Kittle for the Week 2 matchup as both suffered injuries in the season-opening win in Seattle over the Seahawks.
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49ers vs. Saints Full List of Players to Watch
The stage is set for a fascinating Week 2 matchup between the San Francisco 49ers and the New Orleans Saints. The headlines are obvious: Mac Jones gets the start at quarterback, stepping in for the injured Brock Purdy,
Tight end George Kittle will miss at least the 49ers’ next four games on Injured Reserve, and Eddy Piñeiro has replaced kicker Jake Moody.
It's starting to seem like the 49ers expect Christian McCaffrey to play this Sunday in their season opener against the Seahawks.
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