H-RAS, N-RAS and K-RAS GTPases promote cell-cycle progression through the RAF–MEK–ERK/MAPK, RAL and PI3K signalling pathways. Additional RAS-family members, including E-RAS, R-RAS, TC21 and RAL ...
RAS genes constitute the most regularly mutated oncogene family in cancer. Indeed, RAS genes constituted the most regularly mutated oncogenes in the top three causes of cancer deaths in the US in 2016 ...
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