Lactic acidosis represents a challenging metabolic complication in patients with haematological malignancies. Notably, type B lactic acidosis occurs in the absence of hypoxia and is associated with ...

Lactate is the end product of the cytosolic metabolism of glucose, and its accumulation in the blood signals an increase in production or a decrease in utilization, or both. The liver is a major site ...

In this paper, [4] the authors studied a community-based cohort of patients with a diagnosis of diabetes mellitus and a postdiagnosis serum creatinine measurement who were receiving care in the ...

A 58-year-old woman who has adult-onset diabetes mellitus, hypertension, and hyperlipidemia was taking simvastatin (Zocor) 40 mg, glyburide (Diabeta) 20 mg, metformin (Glucophage) 850 mg t.i.d., ...

We retrospectively investigated the clinical and histopathologic features of hospitalized patients infected with human immunodeficiency virus who had symptomatic lactic acidosis syndrome at a ...

Medications may cause elevated lactate levels which could potentially lead to hyperlactatemia and lactic acidosis, according to a systematic review published in the journal Pharmacotherapy. To improve ...

HONG KONG — A new Japanese and U.S. collaborative study showing that inhibition of the oxygen sensor prolyl hydroxylase domain-containing protein 2 (PHD2) in the liver enhanced uptake of lactate for ...

How high can creatinine go before you must stop or alter the metformin dose? —MICHAEL QUIRK, PA-C, Cudjoe Key, Fla. A principal concern in patients using metformin is the development of lactic ...

Metformin-associated lactic acidosis (MALA) is a rare but serious adverse effect of the diabetes drug metformin in which the body accumulates too much lactic acid. Investigators developed and tested a ...