The Seattle Fire Department is asking people to either evacuate or shelter in place at a building on 33rd Avenue South in Rainier Valley.
Firefighters tackled a blaze in the crawl space of a commercial building in the 120 block of North 36th Street.
Video from the scene showed large flames coming from the RV and burning close to nearby power lines.
Firefighters responded to a working fire in Seattle’s Fremont neighborhood on Wednesday morning.
A 31-year-old man was convicted of murder and arson in connection with a 2020 fire at a north Seattle motel that left two people dead.