Get the full 49ers Week 10 practice and media schedule ahead of their matchup vs. the Rams, including press conferences and practice times.

Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

NFL Week 10 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Los Angeles Rams and San Francisco 49ers.

The last of these postseason games came back in 2011 in the NFC Championship game, when the Giants defeated the 49ers on the road, 20-17, to cap off their improbable run to Super Bowl XLVI, where they went on to beat the New England Patriots on that stage for the second time in four years.

Despite their records, the Cardinals have a better point differential than the 49ers. Arizona has scored 180 and allowed 171, while San Francisco has scored 194 and allowed 188. The 49ers have played in one more game though so here’s how that breaks down:

Week 9 vs. Giants with three full practices and media sessions featuring Kyle Shanahan, Robert Saleh, and Klay Kubiak.

Sunday in Tampa, division leaders and MVP contenders square off when Baker Mayfield and the Buccaneers (6-2) host Drake Maye and the New England Patriots (7-2). The NFC South-leading Buccaneers are coming off their bye week and are slight home favorites (-2.

New users can target the DraftKings promo code, which offers $300 in bonus bets if your bet wins + 3 months of NBA League Pass: The model, which simulates every NFL game 10,000 times, is up well over $7,