Membrane progesterone receptors encompass two principal families: the Class II progestin and AdipoQ receptors (mPRα–ε, PAQR7–9) and the membrane-associated progesterone receptor components (PGRMC1/2 ...

Glycine receptors (GlyRs) are pentameric ligand-gated chloride channels that mediate the principal form of fast inhibitory neurotransmission in the spinal cord, brainstem and selected forebrain ...

The human P2X4 receptor plays an important role in chronic pain, inflammation and some types of cancer. Researchers at the University of Bonn and the University Hospital Bonn (UKB) have now discovered ...

"I think PAGER has potential for impact, both in the G protein coupled receptor biology field, and in synthetic circuits or cell-based therapies," said Alice Ting, professor of genetics at the School ...

Ketamine, a drug approved for medical use in 1970 as a short-acting anesthetic, including during the Vietnam War for ...

Humans have about 400 odorant receptors (ORs), but scientists have had trouble finding ligands that match up with most of these ORs in lab settings—leaving them with a murky understanding of how ...

Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...

A poorly characterized protein, historically thought to be a chaperon or enzyme, may actually be a key player in prostate cancer. In a systematic CRISPR screen, scientists from Arc Institute, UCSF, ...

A THC-treated tumor organoid. (Martínez-Illescas et al., Communications Biology, 2026) Cancer cells are proving trickier than ...

A bitter taste has always been considered a warning signal, devoted to protecting us from ingesting potentially harmful substances. But bitter taste receptors can apparently do much more than just ...