P53, a tumor suppressor gene that is mutated and inactivated in the vast majority of cancers, has often been described as the "guardian of the genome" because of its protective effects against cancer.

In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden discussed the unique mutational spectrum of the transformation-related ...

Kretek cigarettes consist of tobacco, cloves, and sauce, with filtered kretek cigarettes having a filter at one end. Cigarette smoke can harm the respiratory system, so it's important to understand ...

In the 1970s, scientists knew that some viruses and chemicals caused cancer, but they didn’t know how. Arnold Levine, a biologist currently at the Institute for Advanced Study researched DNA viruses ...

mRNA injections could reduce aggressive ovarian tumors by rescuing an often mutated gene in high-grade serous ovarian patients, according to a preclinical study. The most common form of ovarian cancer ...

Figure 4: Loss of p53 predisposes to mammary tumors in mice and in women, but penetrance varies among individuals. The prevalence of TP53 mutations in nearly all tumors emphasizes its role as a ...

The results of research headed by a team in the lab of Michael Sigal, MD, at the Max Delbrück Center and Charité—Universitätsmedizin Berlin, have shed new light on the role of the p53 tumor suppressor ...

Researchers found a way to screen cancer-linked gene mutations much more easily and quickly than existing approaches, using a variant of CRISPR genome-editing known as prime editing. Tumors can carry ...