Outcome-adaptive randomization is one of the possible elements of an adaptive trial design in which the ratio of patients randomly assigned to the experimental treatment arm versus the control ...
In an ongoing international, multifactorial, adaptive platform, randomized, controlled trial, we evaluated simvastatin (80 mg daily) as compared with no statin (control) in critically ill patients ...
Pancreatic cancer is a top cause of cancer death in the United States, where the incidence and death rates are on the rise. Each year, more than 60,000 Americans are diagnosed with pancreatic cancer ...
Pancreatic cancer is a top cause of cancer death in the United States, where the incidence and death rates are on the rise. Each year, more than 60,000 Americans are diagnosed with pancreatic cancer ...
A study in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP), published by Elsevier, investigated adaptive treatment for Anorexia Nervosa (AN), a serious psychiatric ...
A Bayesian model and design are described for a phase I-II trial to optimize jointly the doses of a targeted agent and a chemotherapy agent for solid tumours. A challenge in designing the trial was ...
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