Despite partial suppression of NRF2 signaling in the combination group, overall tumor cell death was significantly enhanced, likely due to elevated oxidative stress.

This pathway, known as the Pentose Phosphate Pathway (PPP), metabolizes sugar to produce a critical antioxidant molecule that the cancer cells require to combat oxidative stress. When the researchers ...

University of Kentucky Markey Cancer Center researchers have identified a cellular pathway that fuels the progression of aggressive, drug-resistant prostate cancer. The findings of the study, ...

Researchers identified a direct connection between cancer-related inflammation and the loss of motivation characteristic of advanced cancer. In a mouse study, they describe a brain pathway that starts ...

Targeting cancer metabolism to slow tumor progression To better understand these tumors, the UI researchers used gene editing to create new research models that closely match the cancer-driving ...