An international team of scientists has uncovered the vital role of microglia, the immune cells in the brain that acts as its dedicated defense team, in early human brain development. By incorporating ...

Metastasis occurs when cancer cells break away from the original tumor and travel through the bloodstream to form new tumors in other parts of the body. It is the leading cause of cancer-related death ...

A new study finds that microglia with mutant TREM2 protein reduce brain circuit connections, promote inflammation and contribute to Alzheimer's pathology in other ways. A rare but potent genetic ...

During most eye infections or injuries, neutrophils, immune cells found in the blood, are usually the first line of defense. However, researchers at the Flaum Eye Institute and Del Monte Institute for ...

Immune-regulating brain cells known as microglia are known to play a role in the progression of Alzheimer’s disease (AD). Investigators at Brigham and Women’s Hospital studying the genetics of ...

Mouse microglia got a genetic tune-up. On 9 June in Nature Aging, researchers led by Warren G. Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing human ...

When young donor myeloid cells are transplanted into aging mouse brains, they quickly adopt aging phenotypes. In contrast, old myeloid cells transplanted in young brains take on a more youthful aspect ...

In this interview, Dr. Tilman explains the functions of iPSC-derived microglia and their relevance to conditions like Alzheimer’s and other neurodegenerative diseases. Microglia are the primary immune ...

Nestled within the plasma membrane, γ-secretase trims the ends off membrane proteins. Among its 150 known substrates, none is more famous than APP. The protease chews APPs transmembrane domain to spit ...

A Cedars-Sinai study has identified a previously unknown role for astrocyte cells in how the brain responds to damage and ...