Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory systems are disrupted, cells can acquire the ability to grow uncontrollably ...

Scientists from Duke-NUS Medical School and their international collaborators have developed a new computational tool that maps how gene pathways interact in complex biological systems. Using this ...

Using these models, they then applied state-of-the-art genomic and metabolomic tools to map the metabolic pathways that fuel tumor growth in MPNST. The study, published in Science Advances, found that ...

Generating condition-specific metabolic models by mapping gene expression data to genome-scale metabolic models (GEMs) is a routine approach to elucidate disease mechanisms from a metabolic ...

Arren Bar-Even drove a new way to engineer metabolism; his former collaborators and students are continuing the work ...

A new study published in Nature Genetics has produced the most comprehensive genetic map of human metabolism to date, offering fresh insights into how our genes shape metabolic processes—and their ...

Human microbiome metabolism is intricately linked to health and disease 1. Investigating the relationships between intrinsic (e.g., genetics) and extrinsic (e.g., nutrition) contributing factors ...

The chemicals flowing through your bloodstream tell a story that your DNA alone cannot. They reflect what you eat, how your ...

There are "costs of life" that mechanical physics cannot calculate. A clear example is the energy required to keep specific biochemical processes active—such as those that make up photosynthesis, ...