Scientists have discovered that T cell receptors activate through a hidden spring-like motion that had never been seen before ...

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system. St. Jude Children's Research Hospital scientists recently ...

A hidden “jack-in-the-box” mechanism inside T cells may hold the key to unlocking more powerful cancer immunotherapies.

Efficient T-cell engineering is crucial for the success of CAR T-cell therapy research, but it requires multiple labor-intensive steps, including T-cell isolation, activation, and transduction.

Mayo Clinic researchers have discovered a key reason some cancer patients relapse after receiving chimeric antigen receptor T-cell therapy, or CAR-T cell therapy. Over time, the engineered immune ...

Chimeric antigen receptor (CAR) T cell-based therapy has greatly improved cancer treatment, especially for hematologic cancers. 1 By providing T cells with synthetic receptors that target tumor ...

A rigorous medical journey ends in a breakthrough, in the form of CAR-T therapy, achieving a rare, hard-won cancer-free result.

Researchers at Memorial Sloan Kettering and University Hospital in Würzburg, Germany, have identified a simple way to temporarily switch off CAR T cells with a commonly used drug. The approach could ...

Researchers have unlocked a powerful new way to fight solid tumors using smart immune cells that stay active longer and hit harder. Called EchoBack CAR T-cells, these new cancer-fighting tools work ...

ROCHESTER, Minn. — Mayo Clinic researchers have discovered a key reason some cancer patients relapse after receiving chimeric antigen receptor T-cell therapy, or CAR-T cell therapy. Over time, the ...