Monocyte to lymphocyte ratios and cancer-specific mortality for patients with renal cell carcinoma and inferior vena cava tumor thrombus. Peripheral blood cell counts as biomarkers of clinical benefit ...
Retinal neovascularization (NV), a leading cause of vision loss, results from localized hypoxia that stabilizes the hypoxia-inducible transcription factors HIF-1α and HIF-2α, enabling the expression ...
Interaction between STAT3 and immunosurveillance based on MICA. Background: In hematological malignancies lenalidomide (len) exerts tumoricidal and immunomodulatory effects and may also influence the ...
HIF-1α can stabilize its protein through K63-linked polyubiquitination under hypoxia, stabilized HIF1α proteins dimerize with HIF1β proteins, translocate to the nucleus, and induce transcription of ...
HIF-1α can stabilize its protein through K63-linked polyubiquitination under hypoxia, stabilized HIF1α proteins dimerize with HIF1β proteins, translocate to the nucleus, and induce transcription of ...
MADRID -- Treatment with the hypoxia-inducible factor 2α (HIF-2α) inhibitor belzutifan (Welireg) in advanced, heavily pretreated kidney cancer led to superior outcomes when compared with an older ...
KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the U.S. Food and Drug Administration (FDA) has approved WELIREG, an oral ...
PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...
WELIREG Approved for Adult Patients With VHL Disease Who Require Therapy for Associated Renal Cell Carcinoma, Central Nervous System Hemangioblastomas, or Pancreatic Neuroendocrine Tumors, Not ...
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