Chronic kidney diseases affect more than 10% of the world’s population, and most cases arise from disorders of the kidney’s filtration barrier, which is located within a million microvascular units ...

In the past decade, our understanding of the role of podocytes in the function of the glomerular filtration barrier, and of the role of podocyte injury in the pathogenesis of proteinuric kidney ...

Human kidneys produce more than 4 million litres of virtually protein-free primary urine in a lifetime. In healthy individuals, the sieving process is accomplished by the glomerular filter without the ...

Kidney problems never or rarely announce themselves loudly. There is no sudden pain or obvious warning in the early stages, which often makes it difficult to re ...

Kidneys work quietly in the background, filtering waste, balancing fluids, and maintaining chemical stability without demanding attention. But this is until som ...

Proteinuria is a defining feature of focal segmental glomerulosclerosis, typically accompanied by hypoalbuminemia, hypercholesterolemia, and peripheral edema. The nephrotic syndrome in children is ...

These tiny structures inside the kidney, called glomerular filters, suffer damage from diabetes and grow less effective at filtering the blood. The basic research that led to the clinical trial found ...

Medically reviewed by Robert Burakoff, MD The five stages of chronic kidney disease (CKD) indicate how well the kidneys are working, ranging from stage 1 (mild kidney damage) to stage 5 (kidney ...

Each kidney is made up of approximately one million glomeruli. These filter nitrogenous wastes (like urea and creatinine) from the blood, passing through the tuft of capillaries that make up a ...

Glomerular cell biology is a core strength of the Bristol Renal group. We have an international reputation and numerous collaborations based on our unique conditionally immortalized cell lines. Our ...

Glomerular endothelial cells (GEnC)characterised by non-diaphragmed fenestrations (60-80nm transcellular holes) in their peripheral cytoplasm. The fenestrations occupy a large proportion of the ...