Deep-scale, mass spectrometry-based proteomic studies by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) program involves tissue lysis using urea buffer before data acquisition via mass ...

Self-DNA triggers cGAS-STING-mediated type I interferon (IFN-I) to induce both protective and pathogenic immune responses; however, how self-DNA activates the cytosolic cGAS-STING pathway remains ...

A project at Aston University to extract proteins from cell membranes for better drug discovery and testing has won a Biotechnology and Biological Sciences Research Council (BBSRC) Network grant of ...

Human cells adjust to ever-changing conditions while preserving internal states necessary for survival, but exactly how they achieve both adaptability and stability remains unclear. For the first time ...

Spatial proteomics is a spatial biology method that helps study the spatial distribution of the proteins within cells and tissues. The subcellular localization of proteins is intrinsic to cellular ...

The host cell system is a critical determinant of recombinant protein quality and yield, with direct influence on protein folding and post-translational modification factors that shape the ...

A recombinant protein is a protein made by genetically engineered cells rather than extracted directly from its natural source. Scientists insert the gene for the desired protein into a production ...