Expansion microscopy (ExM) is an attractive route to nanoscale imaging for labs without conventional super-resolution microscopes. It involves linking fluorescent markers through a gel infused into ...

A classical way to image nanoscale structures in cells is with high-powered, expensive super-resolution microscopes. As an alternative, MIT researchers have developed a single-step technique for ...

A classical way to image nanoscale structures in cells is with high-powered, expensive super-resolution microscopes. As an alternative, MIT researchers have developed a way to expand tissue before ...

A collection of protocols covering a variety of methods to achieve super resolution in microscopy to include structured illumination, single-molecule fluorescence and localization-based approaches.

In biology, seeing can lead to understanding, and researchers in Professor Edward Boyden's lab at the McGovern Institute for Brain Research are committed to bringing life into sharper focus. With a ...

Researchers devised a way to expand tissue 20-fold in a single step. Their simple, inexpensive method could pave the way for nearly any biology lab to perform nanoscale imaging. A classical way to ...

Nearly 150 years ago, scientists began to imagine how information might flow through the brain based on the shapes of neurons they had seen under the microscopes of the time. With today's imaging ...

This ×4 expansion microscopy image of a CHO cell reveals the intricate microtubule network (magenta) and overall cellular architecture (green), showcasing both the promise and pitfalls of expansion ...

Ultrastructure expansion microscopy of murine male germ cells reveals the fine molecular structures of centrioles (shown in the enlarged image). DNA is stained in blue, and the chromosome axis in red.

A classical way to image nanoscale structures in cells is with high-powered, expensive super-resolution microscopes. As an alternative, MIT researchers have developed a way to expand tissue before ...