Coming off a comeback win against the New England Patriots on Sunday, the Bills will head to Cleveland to face the Browns at 1 p.m. with a chance to clinch a playoff spot.

The Philadelphia Eagles come in as the NFC East champions, but the Buffalo Bills have work to do to retain their AFC East title when they host this NFL Week 17 matchup. The Eagles (10-5) hit a rough patch and went on a three-game losing skid because of an inconsistent offense but have bounced back to score 60 points in winning their past two games.

The NFC West and the top overall seed in the conference is on the line Saturday at Levi’s Stadium when the San Francisco 49ers (12-4) host the Seattle Seahawks (13-3). Sam Darnold and the Seahawks have won six in a row to take a one game lead into the final game of the regular season.