The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Broncos in NFL ‘Thursday Night Football.’ My Week 9 straight-up picks went 10-4 last week. Let’s see if I can keep the momentum going. I’m giving two picks for each game: One is which team I predict to win outright,

Rams (-4.5) at 49ers: The 49ers are now without Fred Warner, Nick Bosa, and rookie 11th overall pick Mykel Williams for the season. Meanwhile, the Rams are extremely healthy for a Week 10 game. It doesn't matter to me whether Brock Purdy or Mac Jones starts. The Rams are a much better team either way.

With C.J. Stroud ruled out with a concussion, the Texans will turn to Davis Mills in Week 10. While Stroud's absence obviously lowers Houston's ceiling, I still like the Texans in this spot. Mills is a capable backup, and this matchup is more about fading Jacksonville than anything else.

NFL Week 10 picks, predictions, win probabilities for Raiders-Broncos, Falcons-Colts, Jaguars-Dolphins, Browns-Jets, Cardinals-Seahawks, more games.