Route 66 is celebrating its 100th birthday this year. Tripadvisor and Choice Hotels launched a new guide for road trippers.

Every Sunday evening in downtown Albuquerque, New Mexico, shiny, candy-painted lowriders cruise, hop and bounce down Central Avenue as bystanders cheer on the spectacle of artistry and craftsmanship.

There’s something inherently American about hitting the open road. Over the decades, certain cars have become synonymous with the classic road trip. From the early days of motoring to the modern era ...