The slate features several prime-time road games against the NFL's best, a pair of holiday matchups, and a season finale against a friend-turned-foe.

With the NFL schedule officially unveiled, here is Lions OnSI's first game-by-game prediction for the Lions' 2025 season. Week 1 - Sunday, Sept. 7 -- at Packers (4:25 p.m. ET) Prediction: 30-23 win (1-0). Week 2 - Sunday, Sept. 14 -- vs. Bears (1 p.m. ET) Week 3 - Monday, Sept. 22 -- at Ravens (8:15 p.m. ET)